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Facult� de m�decine et des sciences de la sant�

Projects


PROGNOSIS OF EARLY ARTHRITIS


The various classification and diagnostic sets of criteria were established from patients that already had characteristic manifestations for many years. Unfortunately, the same criteria are not applicable in patients with a recent onset of articular manifestations. As a consequence, a longitudinal observational cohort study was initiated in the fall of 1999, studying patients with immune-mediated inflammatory arthritis of recent onset. We are studying the prognostic value of autoantibodies such as anti-CCP and anti-Sa/citrullinated vimentin, alone and in combination with multiple demographic, clinical, biological, serological, genetic, and psychosocial factors. The objective is to identify early on those patients with the most severe and those with the best outcomes.

 

Ro/ANTI-Ro SYSTEM

Our laboratory concentrates on the study of the anti-Ro antibodies and of their targets, the Ro RNPs and particularly their RNA components (the RNA hY1, hY3, hY4, and hY5). Recently, we have identified the presence, in all the primates’ genome, of a very high number of pseudogenes derived from the Y RNAs (representing at least 0.003% of the human genome). These pseudogenes were introduced via a retroposition mechanism using the L1 machinery, by a new mechanism that still needs to be defined. The functional consequences of the multiple insertions of sequences derived from the Y RNAs are one of our current interest of research.